New York, NY, USA
Seeking a post-doctoral research associate in the Department of Microbiology and Immunology. The laboratory projects will involve preclinical modeling that involves a novel E3 ubiquitin ligase (UBR5) and its immunoregulatory activities in tumor cells as well as the associated tumor microenvironment. The primary tumor model systems used will include orthotopic syngeneic and genetically engineered models of breast and ovarian cancers.
a. Liqiu Liao, Mei Song, Xin Li, Lili Tang, Tuo Zhang, Lixing Zhang, Yihang Pan, Lotfi Chouchane, Ma X. 2017. E3 ubiquitin protein ligase UBR5 drives the growth and metastasis of triple negative breast cancer. Cancer Res. Apr 15;77(8):2090-2101. PMID: 28330927
b. Mei Song, Chao Wang, Huan Wang, Tuo Zhang, Jiuqi Li, Robert Benezra, Lotfi Chouchane, Xin-gang Cui, Yin-hao Sun, Ma X. 2020. Targeting Ubiquitin Protein Ligase E3 Component N-Recognin 5 in Cancer Cells Induces a CD8+ T Cell Mediated Immune Response. Oncoimmunology. Apr 14;9(1):1746148. PMID:32363114
c. Song M, Yeku OO, Rafiq S, Purdon T, Dong X, Zhu L, Zhang T, Wang H, Yu Z, Mai J, Shen H, Nixon B, Li M, Brentjens RJ, Ma X. 2020. Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages. Nat Commun. Dec 8;11(1):6298. doi: 10.1038/s41467-020-20140-0. PMID: 33293516