Vignali_Lab Pittsburgh, PA, USA
The successful applicant will work on two related projects, supported by two NIH R01 grants, that will perform structure-function analysis of the inhibitory receptor LAG3 and the TCR:CD3 complex using advanced single molecule microscopy techniques, a variety of signaling techniques, complex mouse models, and other sophisticated immunological techniques. The successful applicant will work with our structural biology collaborators at the University of Maryland who are applying NMR, crystallographic and cryo EM approaches in the project. This positions will focus on gaining a mechanistic understanding and therapeutic development of pathways and processes under investigation. The candidate will also gain considerable experience writing manuscripts, reviews and grants along with oral presentations. Additional duties will include mouse colony management, training of undergraduate and graduate students, participation in department activities, presentations at lab, local and national meetings and any other assignments that the PI may request.
Candidates should have a PhD or MD/PhD (no more than 2 years post second degree), a solid understanding of basic immunology, and ideally practical experience with mouse models of disease. Training grant eligible candidates (US citizens and green card holders) are strongly encouraged to apply.