vazirilab New York, NY, United States
Our lab is focused on the development and application of advanced optical imaging technologies to advance neuroscience.
To develop and advance various optical neurotechnologies based on multiphoton and computational microscopy we have developed over the years, as well as to drive their dissemination by their consolidation, refinement and development of alpha and beta prototype microscopes in collaboration with industrial partners, and through interdisciplinary collaborations, we are currently looking for highly motivated and ambitious candidates to fill staff positions as an Optical / Systems Engineer.
• Development and optimization of new high-speed optical methods for large scale recording of neuronal population activity
• Development of strategies and imaging tools for in vivo imaging in scattering media
• Optimization and dissemination of computational imaging techniques
• Self-driven, ambitious, and motivated by enabling engineering innovations with lasting practical impact
• Track-record as the lead designer and/or experimental constructor of complex (electro) optical and optomechanical systems or instruments
• Ph.D. degree, master’s degree, or bachelor’s degree in physics, optical engineering, electrical engineering, or related area and 2-5 years of relevant work experience in a scientific or industrial research environment
• Experience with one and more of these areas would be highly desired: optical modeling and simulations (e.g. ZEMAX), ultra-fast laser systems, fiber optics, mechanical design, mechanical fabrication skills, RF electronics and electronics design, optomechanical hardware control (LabView, FPGA, experience with large-scale data processing and cluster computing)
• Basic programming skills (e.g. Matlab, Python, LabView, CAD)
• Highly result oriented, excellent time management and communication skills, the ability to effectively work in a team environment between academia and industry, and willingness to work outside of core expertise
1. Andrasfalvy, B., et al., Two-photon Single Cell Optogenetic Control of Neuronal Activity by Sculpted Light. PNAS, (2010). 107(26): 11981-11986.
2. Losonczy, A., et al., Network mechanisms of theta related neuronal activity in hippocampal CA1 pyramidal neurons. Nature Neuroscience, (2010). 13(8): 967-72.
3. Schrodel, T., et al., Brain-wide 3D imaging of neuronal activity in Caenorhabditis elegans with sculpted light. Nature Methods, (2013). 10(10): 1013-1020.
4. Prevedel, R., et al., Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy. Nature Methods, (2014). 11(7): 727-730
5. Prevedel, R. et al., Fast volumetric calcium imaging across multiple cortical layers using sculpted light. Nature Methods, (2016). 13: 1021-1028
6. Skocek,O., et al., High-speed volumetric imaging of neuronal activity in freely moving rodents. Nature Methods, (2018). 15: 429–432.
7. Nöbauer, T., et al., Video rate volumetric Ca2+ imaging across cortex using seeded iterative demixing (SID) microscopy. Nature Methods, (2017). 14: 811-81.
8. Weisenburger, S. et al., Volumetric Ca2+ Imaging in the Mouse Brain using Hybrid Multiplexed Sculpted Light (HyMS) Microscopy. Cell (2019), 177: 1-17.
9. Demas, J., et al., High-Speed, Cortex-Wide Volumetric Recording of Neuroactivity at Cellular Resolution using Light Beads Microscopy. Nature Methods, (2021). 18: 1103-1111.