Scientist I, II or III, Discovery Research – NextCure Inc

  • Postdoc
  • Scientist
  • Scientist with a strong background in cancer immunology
  • Applications have closed
Lab Website:

Beltsville, MD, USA


NextCure is a clinical-stage biopharmaceutical company committed to discovering and developing novel, first-in-class immunomedicines to treat cancer and other immune-related diseases by restoring normal immune function. We are seeking a highly motivated Scientist with a strong background in cancer immunology to join our team. The NextCure Discovery Department employs multiple function-based, high-throughput screening approaches to identify proteins with novel immune function in cancer and other diseases for the development of novel, first-in-class immunotherapies. This position will focus on in vivo disease modeling, as well as in vitro studies, of novel targets identified with our Discovery platforms. The candidate will play a key role in defining the mechanism of action of novel immunomodulatory proteins and validating candidate therapeutic agents. The selected candidate will work in a highly dynamic, proactive, multidisciplinary environment with the goal of rapidly moving novel biological immunomedicines to the clinic.


•Develop, implement, perform, analyze and present results from immune-based in vivo syngeneic and humanized (CDX) murine models
• Adroitly perform various methodologies for in vivo studies including injections (iv, ip, sc) and various tissue recovery (blood/serum, spleen, LN, tumor, etc.) for ex vivo analysis
• Skill in flow cytometry and other standard immunology methods (i.e. ELISA) is required
• Ex vivo analyses of mouse tissues for validation and mechanistic studies
• Utilize high-tech imaging equipment and automation for in vivo imaging and analysis (IVIS)
• Work closely with Project Leads and Project Teams to complete in vivo and in vitro studies
• Engage with collaborators and CROs performing in vivo studies as necessary for specific projects
• Work closely with management and research teams to achieve objectives

Qualifications/Preferred Skillsets:

• PhD in Immunology with a strong background in theoretical, bench and applied research (5+ years; salary and title commensurate with experience)
• Disease relevant in vivo research experience in cancer immunology
• Expert hands-on work skills in in vivo models and in vitro primary and cell-line based assays
• Ability to independently design, develop implement, perform, analyze, interpret, generate reports and present experimental data to project leads, project teams, and Management
• Capable of working well in a team setting to achieve company objectives
• Demonstration of expertise and innovation that will support research and product development at NextCure
• Strong verbal and written communication skills

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