Postdoc in Molecular Imaging, University of Michigan

  • Postdoc
  • Targeted detection, diagnosis, and therapy of cancer
  • Applications have closed
Lab Website: wang_lab

Ann Arbor, MI, USA


Description:

Develop, characterize, and validate peptide ligands that bind cancer-specific targets, including 1) heterodimers for multivalent ligand-target interactions, 2) nanocarriers for site-specific delivery, 3) advanced genomic tools to identify response biomarkers, and 4) small animal imaging (fluorescence, photoacoustic, ultrasound) and therapy, and 5) clinical translation. We use genetics, proteomics, transcriptomics, bioinformatics, biochemistry, and molecular analyses, and single cell RNA-seq analysis of human cells, mouse models, and patient specimens, including organoid cultures.



Qualifications/Preferred Skillsets:

- PhD degree in biochemistry, chemistry, molecular biology, immunology, or related discipline
- Experience with standard molecular biology techniques, cell culture, and small animals
- Ability to work effectively both independently and as a member of a team



Featured Publications:

1. Chen J, et al. Multiplexed endoscopic imaging of Barrett’s neoplasia using targeted fluorescent heptapeptides in a phase 1 proof-of-concept study. Gut 2021;70:1010-13. PMC8108279.
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2. Joshi BP, et al. Wide-field endoscopic imaging of sessile serrated adenomas with fluorescently-labeled peptide probe. Gastroenterology 2017;152:1002-13. PMC5771498.
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3. Sturm MB, et al. Targeted endoscopic imaging of Barrett’s neoplasia with specific fluorescent-labeled peptide: first in-human results. Science Translational Medicine 2013;5:184ra61. PMC3859345.


Something about the PI: Dr. Wang is a physician scientist who has developed a number of novel methodologies for in vivo imaging and therapy in the digestive tract. He has pioneered the use of fluorescence-labeled peptides to detect overexpressed cell surface targets in vivo to identify pre-malignant mucosa. He has mentored numerous visiting scholars, junior faculty, post-docs, clinical fellows, graduate students, medical residents, medical students, and undergraduates. In addition, he has filed over 50 patents on novel imaging technologies.
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