Postdoctoral Fellowship, University of Maryland School of Medicine

  • Postdoc
  • We study how cyclic nucleotide signaling regulates the neurobiology of learning & memory and social behaviors and how that signaling becomes impaired in aging or neuropsychiatric disease.
Lab Website: Kelly-Michy

KickassKe11yLab Baltimore, MD


Description:

The Kelly Lab is recruiting multiple postdoctoral fellows to study how cyclic nucleotide signaling regulates the neurobiology of learning & memory and social behaviors and how that signaling becomes impaired in aging or neuropsychiatric disease. Multiple projects are available, including those centered on circuit-level analyses (e.g., optogenetics, chemogenetics, fiber photometry), proteomics (identifying protein binding partners and signal transduction cascades), and drug discovery (both small molecule and biologics).
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What we will offer you:
• Strong mentorship in experimental design, grant/publication writing and career development
• Organized and goal-oriented work environment
• Friendly and supportive team of researchers
• Opportunities to present at national/international conferences
• A highly collaborative department and school full of state-of-the-art facilities
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Interested parties should send their CV and key pubs along with a cover letter that explains how your experience and personality makes you a fit for these positions (that is, tell me why I should interview you instead of someone else 😊).



Qualifications/Preferred Skillsets:

You are a fit for the Kelly Lab if you have:
• A strong background in neuroscience, biochemistry, and/or proteomics
• An ability to independently digest relevant literature and formulate ideas
• Strong writing and communication skills
• Excellent time management skills
• Experience handling mice and/or rats
• An appreciation for the color teal (official lab color)
• An ability to embrace a diverse “girl power” culture
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You should additionally have strong experience with at least some of the following skillsets:
• Rodent behavior
• Optogenetics or chemogenetics
• Stereotactic surgery
• Fiber photometry
• Proteomics (e.g., identifying protein binding partners)
• Cell culture
• Basic molecular biology and biochemical techniques



Featured Publications:

Smith A, Farmer R, Pilarzyk K, Porcher L, Kelly MP* (in press). A genetic basis for friendship? Homophily for membrane-associated PDE11A-cAMP-CREB signaling in CA1 of hippocampus dictates mutual social preference in male and female mice. Molecular Psychiatry. Epub ahead of print. DOI: 10.1038/s41380-021-01237-4. [Featured in: New York Post, LabRoots, WOKV-AM radio, News-Medical.net, Science Daily, Technology Networks, Neuroscience News Online, U.S.A.NewsWall.com, techilive.com, NewsCaf, MedicallyPrime.com, Science Newsnet, Medical Xpress, Newswise, Mirage News Australia, EurekaAlert.org]

Porcher L, Bruckmeier S, Burbano SD, Finnell JE, Gorny N, Klett J, Wood SK, Kelly MP* (in press) Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions. Journal of Neuroinflammation.
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Farmer R, Burbano SD, Patel NS, Sarmiento A, Smith AJ, and Kelly MP* (2020) Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease Cellular Signalling. 70: article 109592. doi.org/10.1016/j.cellsig.2020.109592.
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Baillie G, Tejeda G, and Kelly MP* (2019) Therapeutic targeting of 3’,5’-cyclic nucleotide phosphodiesterases: Inhibition and beyond. Nature Reviews Drug Discovery. 18(10):770-796. DOI : 10.1038/s41573-019-0033-4 [Peer-reviewed Invited Review]
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Pilarzyk K, Klett J, Pena E, Porcher L, Smith AJ, Kelly MP* (2019) Loss of function of phosphodiesterase 11A shows recent and remote long-term memory can be uncoupled. Current Biology. 29:2307-2321. https://doi.org/10.1016/j.cub.2019.06.018



Salary: NIH scale
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