bensahralab Chicago, IL, USA
A postdoctoral position is available in the laboratory of Dr. Issam Ben-Sahra to understand how cellular metabolism is regulated in normal and cancer cells. Dr. Issam Ben-Sahra is an Assistant Professor at the Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago. The Feinberg School of Medicine is in the center of downtown Chicago. Further information about the Ben-Sahra lab can be found at: https://www.feinberg.northwestern.edu/sites/biochem/research/labs.html#ben-sahra
Dr. Ben-Sahra and the Ben-Sahra lab have established new connections between major signaling pathways, such as ERK (extracellular signal-regulated kinases) and mTORC1 (mechanistic Target of Rapamycin Complex 1) and the regulation of nucleotide metabolism (Ben-Sahra et al., Science 2013, Science 2016, Ali, Sahu, et al., Molecular Cell 2020, Villa et al., Molecular Cell 2021). Current research focuses on key molecular links between metabolic and oncogenic signals and cellular metabolism in vitro and in vivo. We aim to identify the metabolic and signaling nodes that are essential for cell physiology.
Western blot, Metabolism, CRISPR screens, Metabolic assays, Mouse work.
Candidates must have a Ph.D. or equivalent with solid research experience in biochemistry, cell biology, molecular biology, and animal models. Applicants with expertise in CRISPR screens will be preferred.
We are looking for brilliant and enthusiastic people to join our team. Interested applicants should submit a PDF file including a complete CV, a brief description of their research achievements and interests, the name and contact details for three referees to: firstname.lastname@example.org
Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I. mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis. Molecular Cell. 2021 Mar 17:S1097-2765(21)00177-5. doi: 10.1016/j.molcel.2021.03.009.
Ali ES, Sahu U, Villa E, O’Hara BP, Gao P, Beaudet P, Wood AW, Asara JM, Ben-Sahra I.
ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis. Molecular Cell. 2020 May 28:S1097-2765(20)30302-6. doi:10.1016/j.molcel.2020.05.001.
Ben-Sahra I, Hoxhaj G, Ricoult SJ, Asara JM, Manning BD. mTORC1 induces de Novo Purine Synthesis Through Control of the Mitochondrial Tetrahydrofolate Cycle. Science 12 Feb 2016:
Vol. 351, Issue 6274, pp. 728-733 DOI: 10.1126/science.aad0489
Ben-Sahra I, Howell JJ, Asara JM, Manning BD. Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science. 2013 Mar 15;339(6125):1323-8. doi: 10.1126/science.1228792. Epub 2013 Feb 21