Postdoctoral Fellow, UT Southwestern

  • Postdoc
  • Studying T cell exhaustion in cancer immunology
Lab Website: tuoqi-wu.html

Dallas, Texas


Description:

A postdoctoral fellow position is open in the laboratory of Dr. Tuoqi Wu in the Department of Immunology and the Harold C. Simmons Comprehensive Cancer Center at the UT Southwestern Medical Center. The Wu laboratory aims to understand the molecular programs governing T cell stemness and exhaustion during cancer and chronic viral infection and to identify targets to improve the antitumor T cell response during immunotherapies. Studies will utilize cutting-edge next-generation sequencing, CRISPR-Cas9 knockout screen, bioinformatics as well as molecular and cellular immunology approaches. Dr. Wu received his PhD degree from Emory University. He performed his postdoctoral research at the National Institutes of Health (NIH). Dr. Wu is currently an assistant professor in the Department of Immunology at the UT Southwestern Medical Center. His research is supported by the NIH, V foundation, American Federation for Aging Research, and generous startup fund from UT Southwestern.



Qualifications/Preferred Skillsets:

• PhD degree in immunology, microbiology, cancer biology or relevant fields
• Experience with molecular biology
• Comfortable working with mice and/or patient samples



Featured Publications:

1. Yao C*, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D’Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, Afzali B, Gattinoni L, Zhu Y, McGavern DB, O’Shea JJ, Schwartzberg PL, Wu T*. BACH2 Enforces the Transcriptional and Epigenetic Programs of Stem-Like CD8 T cells. Nature Immunology, 2021 Mar;22(3):370-380. PMID: 33574619 *corresponding authors.
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2. Yao C, Sun HW, Lacey NE, Ji Y, Moseman EA, Shih HY, Heuston EF, Kirby M, Anderson S, Chen J, Khan O, Handon R, Reilley J, Fioravanti J, Hu J, Gossa S, Wherry EJ, Gattinoni L, McGavern DB, O'Shea JJ*, Schwartzberg PL*, Wu T*. Single-Cell RNA-Seq Reveals TOX as a Key Regulator of CD8+ T cell Persistence in Chronic Infection. Nature Immunology, 2019 Jul;20(7):890-901. PMID: 31209400 *corresponding author
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3. Wu T*, Ji Y, E. Moseman EA, Manglani M, Kirby M, Anderson S, Handon R, Kenyon E, Elkahloun A, Wu W, Gattinoni L, McGavern DB, Schwartzberg PL*. The TCF1-Bcl6 axis counteracts type I interferon to repress T cell exhaustion and maintain T cell stemness in chronic viral infection. Science Immunology, 2016 Dec 23;1(6):eaai8593. PMID: 28018990 *corresponding authors.


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