New York, NY, USA
An NIH-funded Postdoctoral Fellow position is available at the Icahn School of Medicine at Mount Sinai in New York City to participate in studies on the function of immune-related (inflammation) genes induced by steroid hormones in mammalian hematopoietic stem/progenitor cells and in erythropoiesis at steady-state and under conditions of stress. We have been studying nuclear hormone transcription factor regulation of erythropoiesis (e.g. see Barminko et al. (2018) Blood Advances 2:1207-1219) and have carried out bulk and single cell RNAseq analyses implicating a number of pathways, including inflammation and immune pathways, in erythroid and other hematopoietic progenitors. Projects will include but will not be limited to: functional analysis of selected genes using knockdown and/or knockout studies in cultured cells and/or mouse lines; computational analysis of bulk and scRNAseq data; protein biochemistry to study transcription factor function; ATACseq analysis of transcription factor (vitamin D receptor, glucocorticoid receptor) binding to chromatin.Responsibilities:
experimental work, critical reading of relevant literature, drafting of abstracts and manuscripts, some supervision of less experienced lab members.
• PhD, MD, MD/PhD or equivalent
• Strong record of accomplishment and experience in molecular and cellular biology
• Expertise in hematopoiesis and/or gene regulation desirable
• Experience with fluorescence microscopy, flow cytometry, and cell culture desirable
• Highly motivated and fluent in English
• Collegial and able to work independently
• At least one recent first author publication in reputed international journal
• Salary support based on research experience and accomplishments.
• U.S. citizen or Permanent Resident; if already in U.S., must have visa valid for at least 1 more year.
Salary: Commensurate with experience, starting at $58,800.