Postdoctoral Fellowship, Icahn School of Medicine at Mount Sinai

Description:

An NIH-funded Postdoctoral Fellow position is available at the Icahn School of Medicine at Mount Sinai in New York City to participate in studies on the function of immune-related (inflammation) genes induced by steroid hormones in mammalian hematopoietic stem/progenitor cells and in erythropoiesis at steady-state and under conditions of stress. We have been studying nuclear hormone transcription factor regulation of erythropoiesis (e.g. see Barminko et al. (2018) Blood Advances 2:1207-1219) and have carried out bulk and single cell RNAseq analyses implicating a number of pathways, including inflammation and immune pathways, in erythroid and other hematopoietic progenitors. Projects will include but will not be limited to: functional analysis of selected genes using knockdown and/or knockout studies in cultured cells and/or mouse lines; computational analysis of bulk and scRNAseq data; protein biochemistry to study transcription factor function; ATACseq analysis of transcription factor (vitamin D receptor, glucocorticoid receptor) binding to chromatin.

Responsibilities:

experimental work, critical reading of relevant literature, drafting of abstracts and manuscripts, some supervision of less experienced lab members.

Qualifications/Preferred Skillsets:

• PhD, MD, MD/PhD or equivalent
• Strong record of accomplishment and experience in molecular and cellular biology
• Expertise in hematopoiesis and/or gene regulation desirable
• Experience with fluorescence microscopy, flow cytometry, and cell culture desirable
• Highly motivated and fluent in English
• Collegial and able to work independently
• At least one recent first author publication in reputed international journal
• Salary support based on research experience and accomplishments.
• U.S. citizen or Permanent Resident; if already in U.S., must have visa valid for at least 1 more year.

Something about the PI: Margaret H. Baron, MD PhD, is Irene and Arthur M. Fishberg Professor of Medicine; Senior Associate Dean for MD/PhD Education and Co-Director of the MD-PhD Program; Program Director of an NIH-funded T32 Medical Scientist Training Program (MSTP); and a member of the Tisch Cancer Institute(TCI) and Black Family Stem Cell Institute (BFSCI). Dr. Baron is an established scientist who has over 30 years of continuous, independent NIH-sponsored research funding in hematopoiesis and gene regulation and a publication record spanning protein biochemistry, virology, cell biology, developmental biology, and stem cell biology. She is known for her work on the plasticity of the differentiated state, globin gene regulation, and developmental hematopoiesis.