Research Laboratory Manager, Icahn School of Medicine at Mount Sinai

  • Function of immune-related (inflammation) genes induced by steroid hormones in mammalian hematopoietic stem/progenitor cells and in erythropoiesis at steady-state and under conditions of stress.

New York, NY, USA


Description:

An NIH-funded lab manager position is available immediately to investigate molecular mechanisms of stem and progenitor cell fate specification. Outstanding opportunity for individual with strong leadership, organizational, and bench skills. Note that this is a research position, not an administrative position. The selected individual will participate in studies on the function of ligand activated nuclear hormone transcription factors (particularly vitamin D and glucocorticoid receptors, VDR and GR) in mammalian erythropoiesis at steady-state and under conditions of stress. We are currently investigating the possible involvement of immune/inflammation pathways in the mechanisms by which VDR and GR regulate erythroid progenitors. These studies may lead to the identification of novel molecular targets in erythroid progenitors that can be exploited to develop new therapies for anemias and other red cell disorders. Interested candidates must have a strong record of accomplishment and experience in molecular and cellular biology techniques such as mammalian cell culture, qPCR, basic DNA subcloning, western blotting, as well as advanced techniques such as flow cytometry, cell sorting, gene knockdowns and confocal microscopy. Expertise in hematopoiesis and/or gene regulation desirable. Experience in computational analysis of transcriptomic data desirable. The candidate will be expected to thoroughly review existing literature to devise and conduct experiments with limited supervision, analyze and record the resulting data meticulously, and present at weekly lab meetings. They will also oversee lab members involved in breeding, maintaining and genotyping our mouse colony and will assist as needed. Experience with fluorescence microscopy, flow cytometry, mouse husbandry and mammalian cell culture desirable but not essential. Applicant must be highly motivated and fluent in English, collegial and able to work independently. Salary support based on research experience and accomplishments.


Responsibilities:

1. Conduct and design experiments independently under the direction of lab Principal Investigator (PI) using advanced research techniques; perform basic molecular and cellular biology methods such as basic molecular subcloning and real-time RT-PCR, mammalian cell culture, mouse husbandry, flow cytometry, and microscopy. Must be able to read, understand, and interpret scientific literature relevant to the research.
2. Report research progress to PI orally, at laboratory group meetings, and in written progress reports and maintain a current knowledge of relevant literature.
3. Maintain good written laboratory records and contact with collaborators.
4. Summarize experimental data and assist in drafting publications under the direction of the PI. Assist the PI with publications by extracting and compiling moderate to complex research data from the relevant literature; assist in interpreting the data; write drafts of and edit manuscripts.
5. Master computer and technical skills necessary for experimental execution as well as data input and analysis.
6. Mentor and train less experienced research staff and graduate students in research techniques and use of equipment.
7. Perform other related duties as assigned.


Qualifications/Preferred Skillsets:

Education:
• Bachelor’s degree in Science or closely related field required; A Master’s or PhD degree preferred.
Experience:
• 3+ years of related research and laboratory experience.
• Proficiency in molecular and cell biology (including subcloning of DNA, PCR, isolation of RNA), basic protein methods (e.g. immunoblotting), flow cytometry, and mammalian cell culture required.
• Expertise in hematopoiesis and/or gene regulation desirable.
• Mouse modeling and handling experience.
• Expertise in computational biology (e.g. RNAseq, scRNAseq, ATACseq) desirable.
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Key Skills:
• Knowledge of standard research concepts
• Excellent organizational, problem solving and analytical skills
• Excellent verbal, written and interpersonal communication skills in English essential
• Knowledge of standard research concepts
• Aptitude for quick learning and multi-tasking is critical
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Citizenship or Visa Status:
Must be U.S. citizen or Permanent Resident; if already in U.S., must have visa valid for at least 1 more year.


Something about the PI: Margaret H. Baron, MD PhD, is Irene and Arthur M. Fishberg Professor of Medicine; Senior Associate Dean for MD/PhD Education and Co-Director of the MD-PhD Program; Program Director of an NIH-funded T32 Medical Scientist Training Program (MSTP); and a member of the Tisch Cancer Institute(TCI) and Black Family Stem Cell Institute (BFSCI). Dr. Baron is an established scientist who has over 30 years of continuous, independent NIH-sponsored research funding in hematopoiesis and gene regulation and a publication record spanning protein biochemistry, virology, cell biology, developmental biology, and stem cell biology. She is known for her work on the plasticity of the differentiated state, globin gene regulation, and developmental hematopoiesis.

Salary: Commensurate with education, training and experience.
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