Palo Alto, CA, USA
We are seeking a translational research scientist experienced in cell biology, genetics, and molecular biology to join the Prolo Lab in the Department of Neurosurgery, Stanford University School of Medicine. The successful candidate will work on projects aimed at discovering molecular mechanisms driving pediatric high-grade glioma growth and invasion with the goal of developing novel therapeutic strategies. The candidate will work within a collaborative environment and will be expected to both lead independent projects and work with other team members.
Pediatric brain tumors are the leading cause of cancer-related death in children and effective treatments are lacking. The goal of our lab is to employ broad-based genetic and epigenetic-screening approaches with CRISPR-Cas9 technology, single cell RNA-seq, and proteomics to better understand the malignant features of childhood brain tumors and to ultimately design effective treatment strategies. The applicant would be part of an exciting research effort that comprises interdepartmental collaborations at Stanford and with outside institutions
We are seeking a highly self-motivated individual with an outstanding track-record of innovation and success in graduate school and postdoctoral research with a sustained record of first-author publications. The candidate will work independently and collaboratively to design and conduct laboratory experiments in patient derived tumor models and in rodent xenograft models. They will have a background in genetic and epigenetic profiling of tumors, familiarity with CRISPR/Cas9 technology, metabolomics, cell culture, DNA recombinant methods and plasmid cloning, imaging and quantitative analyses, biochemistry including Western blotting and protein purification, manuscript preparation, grant preparation and protocol submissions.
Required qualifications include a PhD degree with at least 5 years of experience in genetics, molecular, cellular or cancer biology in academia or industry. A strong background in molecular biology, cell culture, assay development and microscopy are essential. Patient derived tumor modeling and mouse handling experience are desirable. The ideal candidate must be technically rigorous and organized. Integrity and attention to detail are essential skills. The candidate will have excellent oral, written and interpersonal communication skills, be able to work independently and collaboratively, and will help with training of postdoctoral fellows, students and research assistants.
-The minimal qualifications are a PhD with a focus in cell biology, molecular biology, genetics, cancer biology, or related field.
-At least 5 years of experience in academia or industry with methods relevant to genetics, cell biology, biochemistry, molecular biology, and cancer biology (i.e. DNA recombinant methods, plasmid cloning, imaging and quantitative analysis, Western blotting).
-Willingness to help with manuscript and grant preparation as well as protocol submissions
-Desire to mentor and train students in the lab
-Desire to stay up to date on current literature relevant to pediatric brain tumors
-Motivation to work in a small group setting and pursue collaborative opportunities
-Excellent communication and writing skills
-Record of first-authorship publications in peer-reviewed high-quality scientific journals.
-Attention to detail and integrity
-Technically rigorous and organized