Postdoc, University of Pittsburgh

  • Postdoc
  • Post-doctoral fellowship investigating the interaction of T cells and the microbiota in the intestine
Lab Website: www.thehandiestlab.com

thehandiestlab Pittsburgh, PA


Description:

Postdoctoral associate position in Mucosal Immunology is available in the laboratory of Dr. Timothy Hand (www.thehandiestlab.com) at the University of Pittsburgh and UPMC Children’s Hospital of Pittsburgh. The candidate will be performing research in the area of T cell biology in the intestine, with a particular focus on interactions with microbiota that are relevant to vaccine efficacy and immunotherapy against cancer. We have an established program investigating how microbiota-driven T cell responses affect multiple aspects of host physiology and are looking for a postdoc to continue those studies.


Responsibilities:

The candidate will perform independent, mentored post-doctoral research in the Laboratory of Immunity to Bacterial Colonization.


Qualifications/Preferred Skillsets:

The Laboratory of Immunity to Bacterial Colonization is seeking competitive candidates who have recently earned a PhD, possess excellent written and verbal English communication skills, outstanding critical thinking and problem-solving skills and the ability to work as part of a team. Experience in standard immunology and microbiology assays such as multi-color flow cytometry, primary immune cell isolation, cell culture, and molecular biology are required. Experience with microscopy and bioinformatics skills (RNAseq, scRNAseq and microbiome analysis) will be highly valued. Salary is commensurate with experience and based on current NIH guidelines.



Featured Publications:

1) Bhattacharjee A., Burr A.H.P., Overacre-Delgoffe A.E., Tometich J.T., Yang D., Huckestein B.R., Linehan J.L., Spencer S.P., Hall J.A., Harrison O.J., Fonseca D.M., Norton, E.B., Belkaid Y. and T.W. Hand. Environmental Enteric Dysfunction induces intestinal regulatory T cells that inhibit local CD4+ T cell responses and impair the efficacy of oral vaccines. Immunity. 2021 Aug 10;54(8):1745-1757 PMID: 34348118
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2) Overacre-Delgoffe A.E., Cillo A.R., Bumgarner H.J., Burr A.H.P., Tometich J.T., Bhattacharjee A., Bruno T.C., Vignali D.A.A. and T.W. Hand. Microbiome-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer 2021. Immunity, In Press. BioRXIV. https://doi.org/10.1101/2021.01.27.428417.
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3) Gopalakrishna K.P., Macadangdang B.R., Rogers M.B., Tometich J.T., Firek B.A., Baker R., Ji J., Burr A.H.P., Ma C., Good M., Morowitz M.J. and T.W. Hand. 2019 Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants. Nature Medicine. 2019 Jun 17. Jul;25(7):1110-1115 PMID: 31209335.



Salary: NIH standard salary
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