Postdoctoral Associate, University of Pittsburgh

  • Postdoc
  • The role of regulatory T cells (Tregs) within the human tumor microenvironment.
  • Applications have closed
Lab Website: www.vignali-lab.com

Vignali_Lab Pittsburgh, PA, USA


Description:

With the support of a new seven-year NCI R35 grant, the successful applicant will investigate the role of regulatory T cells (Tregs) within the human tumor microenvironment with the goal of understanding novel mechanisms that control their function and survival, and identifying and developing Treg-specific targets for therapeutic intervention. This project will emphasize analysis of fresh samples or tissue sections from banked samples derived from a variety of human cancers using a variety of complex system biology approaches (scRNAseq and CRISPR), several multispectral imaging approaches and other sophisticated immunological techniques. This positions will focus on gaining a mechanistic understanding and therapeutic development of pathways and processes under investigation. Candidates will also develop skills in wide variety of techniques, such as mouse models of cancer, analysis of human tumor samples, immune function assays, flow cytometry, single molecule microscopy techniques, a variety of signaling techniques, system biology approaches (scRNAseq and CRISPR), several multispectral imaging approaches, molecular biology techniques, etc. The candidate will also gain considerable experience writing manuscripts, reviews and grants along with oral presentations. Additional duties will include training of undergraduate and graduate students, participation in department activities, presentations at lab, local and national meetings and any other assignments that the PI may request.



Qualifications/Preferred Skillsets:

Candidates should have a PhD or MD/PhD (no more than 2 years post second degree), a solid understanding of basic immunology, and ideally analysis of human tumor samples. Training grant eligible candidates (US citizens and green card holders) are strongly encouraged to apply.


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