Postdoctoral Research Associate, University of Pittsburgh

  • Postdoc
  • Study the mechanisms whereby leukemia cells resist T cell immunotherapies using novel mouse models, CRISPR-editing and high content genomics
  • Applications have closed
Lab Website: warren-d-shlomchik

Pittsburgh, PA, USA


Description:

Seeking a postdoctoral fellow to study the mechanisms whereby blood cancers resist and escape adoptive T cell immunotherapies. This newly NIH R01-funded project employs mouse leukemias created from compound oncogene knockin/knockout mice. These leukemias will be CRISPR-edited to investigate critical pathways that govern resistance and sensitivity to T cell attack. Other techniques that will be employed include single cell RNA sequencing, the creation and use of novel T cell receptor knockin mice, high parameter flow cytometry and intravital two photon microscopy. Candidates will also gain experience in writing manuscripts and grants and in giving oral presentations.



Qualifications/Preferred Skillsets:

A background in immunology or cancer biology or experience in CRISPR-editing is preferred.



Featured Publications:

1. Zhou, M., Sacirbegovic, F., Zhao, K., Rosenberger, S. & Shlomchik, W. D. T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect. Nature communications 11, 4227, doi:10.1038/s41467-020-17991-y (2020).
2. Morin-Zorman, S., Wysocki, C., Zhu, J., Li, H., Zorman, S., Matte-Martone, C., Kisanga, E., McNiff, J., Jain, D., Gonzalez, D., Rothstein, D. M., Lakkis, F. G., Haberman, A. & Shlomchik, W. D. In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease. Blood Adv 3, 2082-2092, doi:10.1182/bloodadvances.2019000227 (2019).
3. Matte-Martone, C., Liu, J., Zhou, M., Chikina, M., Green, D. R., Harty, J. T. & Shlomchik, W. D. Differential requirements for myeloid leukemia IFN-gamma conditioning determine graft-versus-leukemia resistance and sensitivity. J Clin Invest 127, 2765-2776, doi:10.1172/JCI85736 (2017).


Something about the PI: Warren Shlomchik is Professor of Medicine and holder of the Endowed Chair in Cancer Immunology. He is also the Director of Hematopoietic Stem Cell Transplantation and Cell Therapies at the University of Pittsburgh/University of Pittsburgh Medical Center.
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