Postdoctoral Fellowship iPSC Models for Autism

  • Postdoc
  • Applying developmental neuroscience and genomic techniques to novel induced pluripotent stem cell (iPSC) models of key autism risk genes.
Lab Website: oroak-lab

TheRealDrOLab Portland, Oregon, USA


Description:

A Postdoctoral Scholar position with a focus on applying developmental neuroscience and genomic techniques to novel induced pluripotent stem cell (iPSC) models of key autism risk genes is immediately available in the laboratory of Dr. Brian J. O’Roak in the Department of Molecular and Medical Genetics at Oregon Health & Science University (OHSU), Portland OR. Previous experiences with iPSCs, 2D neuronal differentiation, and/or 3D brain organoid (spheroid), and single-cell -omics are strongly preferred.



Qualifications/Preferred Skillsets:

Required Qualifications
• PhD, MD or MD/PhD in neuroscience, cell/molecular biology, genetics or related field
• Experience in and a strong interest in induced pluripotent stem cells and developmental neuroscience
• Demonstrated ability to work independently and learn new techniques quickly
• Candidates must be well organized, self-motivated and dependable
• Excellent communication skills with the ability to plan, document, analyze and report data
____________________
Preferred Qualifications
• Intensive training in the areas of iPSCs, genetics/genomics, computer science, or bioinformatics
• Expertise in microscopy, 2D and 3D neuronal culture
• Previous experience analyzing –omics datasets
• Familiarity with statistics and optimal study design



Featured Publications:

Mulqueen et al. Improved single-cell ATAC-seq reveals chromatin dynamics of in vitro corticogenesis. doi: https://doi.org/10.1101/637256


Something about the PI: Highlights of Dr. O’Roak’s past research successes include: pioneering trio-based exome sequencing in simplex autism and developing new technologies for rapid and economical targeted resequencing. We are building on this experience with a strong and diverse research group focused on developing and implementing cutting-edge methods and technologies for discovery and replication, molecular diagnosis, functional dissection of pathways, and targeted therapeutics for neurodevelopmental and related disorders. This work has the potential to dramatically improve the lives of individuals affected with these currently untreatable disorders through early intervention and biologically based personal therapies.

Salary: NIH scale
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