Post Doc Fellow -Children’s Hospital of Philadelphia

  • Postdoc
  • Molecular basis of coagulation

Philadelphia, Pennsylvania


Postdoctoral fellow positions are available at The Children's Hospital of Philadelphia (CHOP) Research Institute, an interdisciplinary institution dedicated to conducting basic, clinical and translational research on conditions and diseases that affect children.
Dr. George’s laboratory studies the molecular basis of coagulation and how disturbances in their function lead to disorders of bleeding and thrombosis. We are also interested in translating basic molecular and biochemical insights to improve therapeutics for disorders of hemostasis, namely hemophilia. Specifically, we are interested in developing novel gene therapy approaches for hemophilia and understanding the mechanism of inhibitor formation in hemophilia.
The postdoctoral fellow (postdoc) will have a terminal degree PhD, MD, or MD-PhD and will, under the direction/guidance of a mentor (Dr. Lindsey A. George, M.D.) assume responsibility for a specific, on-going research project around mechanisms that regulate coagulation factor VIIIa and the potential clinical translation considerations in the context of gene therapy for hemophilia A. The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group. Postdocs will be expected to participate in/lead project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.
A variety of enzymatic, biochemical, and molecular biological techniques are used in the laboratory in order to carry out our specific goals. For example, the following techniques are routinely preformed in the laboratory: modern molecular methods (site-directed mutagenesis, cloning, etc.), tissue culture, protein purification, HPLC, FPLC, SDS-PAGE, ELISA, enzymatic kinetic assays, fluorescence spectroscopy, fluorescence anisotropy measurements, mouse modeling of hemostasis, designing AAV vectors etc. Experience with murine models is also desirable.

We routinely interact with a large group of basic, translational and clinical investigators at CHOP and the University of Pennsylvania School of Medicine that collectively comprise an enriched hemostasis and thrombosis as well as gene therapy community for both training and collaboration. Highly competitive salary and benefits are offered.
Curriculum vitae should be sent to:
Dr. Lindsey George, The Children’s Hospital of Philadelphia, CTRB, Rm. 5016, Philadelphia, PA 19104. Email:
More info can be found at:


-Conduct independent scholarly research and develop new methods and protocols
-Participate in project planning, recording and evaluation of data
-Acquire technical, lab management and grant writing skills
-Participate in seminars, lectures, poster sessions and presentation at national meetings
-Supervise junior lab members
-Assist with other research projects
Postdoctoral fellows at The Children's Hospital of Philadelphia receive mentored training in a rich scientific and collaborative environment that includes the resources of the adjacent University of Pennsylvania. Visit for more information about The Children’s Hospital of Philadelphia Research Institute and its research programs.

Qualifications/Preferred Skillsets:

-A terminal degree PhD, MD, DVM, etc.
-According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing
All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.
Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.
Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.
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Talent Acquisition
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Philadelphia, PA 19146

Link to Application (if using external Application Portal):
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