Los Angeles, California, USA
We are seeking a highly motivated postdoctoral fellow/postdoc to expand our iPSC modeling of BRCA1 cancers using fallopian tube organoid technology recently published in Cell Reports. We want now to generate more lines and learn how over-expression of “second hit” genes may accelerate tumor progression and lead to enhanced models of disease. Our laboratories have ongoing discovery projects directed at key molecules driving cancer growth, metastasis, and tumor microenvironment (TME, stroma/fibroblast) along with cutting-edge iPSC and organoid technologies. Together we are using these systems to evaluate candidates for therapeutic targeting and clinical translation to trials in patients.Responsibilities:
-May assist in the preparation of grant proposals, submissions, publications, and presentations but is not responsible for generating grant funds.
-Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.
-May write/modify IRB and IACUC applications.
-May mentor/train research associates, technicians, and students.
-Participation in laboratory meetings, keeping a lab notebook, performing calculations, tabulating data, summarizing methods and results of related experiments, and general lab maintenance.
-Operates and maintains equipment and instruments.
-Driven, creative, team-oriented individual with a passion for helping to discover and move fundamental cancer biologic findings towards a clinical setting.
-PhD or MD/PhD degree. We welcome applications who are completing their Ph.D. as well as individuals seeking additional postdoctoral training. Strong preference will be given to individuals with an outstanding publication record from their prior graduate and/or postgraduate training and/or existing external funding.
-Background in stem cell tissue culture, functional genomics (including CRISPR, shRNA, and cDNA library use), and next-generation sequencing.
-A broad-based knowledge of stem cells, organoids, cancer biology, immunology, and signal transduction.
-Acquires thorough technical and theoretical knowledge of research projects and objectives during one to five (1-5) year post-doctoral appointment.
-Works independently on research projects designed by a mentor (typically the PI) within the area of specialization.
-Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, analysis, and operation.
-Experienced in research animal husbandry and handling.
-Scheduling flexibility including evening, weekend, and holiday rotation commitment may be necessary. Travel may be required.
-Function efficiently and cooperatively with a team of faculty, research associates, technicians, and students.
-Excellent written and oral communication skills are essential.
-Knowledge of safety standards and maintenance of specialized equipment.
Link to Application (if using external Application Portal): https://jobs.cedars-sinai.edu/job/los-angeles/postdoctoral-scientist-svendsen-and-theodorescu-labs-regenerative-medicine-institute-and-cancer-pro/252/21679571184