Postdoc Leukodystrophy Center, Children’s Hospital of Philadelphia

  • Postdoc
  • Therapeutic development - using in vivo and in vitro models - for key leukodystrophyies

ChildrensPhila Philadelphia, PA


Description:

The Research Post-Doctoral Fellow will support basic science research projects within the Leukodystrophy Center a cutting-edge translational program at the Children's Hospital of Philadelphia that supports therapeutic development for a group of approximately 31 rare genetic disorders that affect development of the white matter of the brain, predominantly in pediatric populations. Current projects are focused on therapeutic development - using in vivo and in vitro models - for key leukodystrophyies such as Hypomyelination and Atrophy of Basal Ganglia and Cerebellum (H-ABC), Aicardi-Goutières Syndrome (AGS), and Alexander Disease.

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The Leukodystrophy Center is currently seeking candidates for a post-doctoral position to focus on a research project involving development of novel therapeutic approaches using adeno-associated virus (AAV)-based gene therapy and antisense oligonucleotides (ASOs) in these target disorders. The position will include opportunities to participate in the design, optimization, and establishment of feasibility and safety of the proposed therapeutic approaches preparatory to clinical development. The laboratory, under the direction of Dr. Adeline Vanderver, MD, uses a variety of advanced scientific techniques, such as immunohistochemistry, confocal microscopy, stereotaxic surgery, and molecular biology assays. The post-doctoral fellowship includes participation in various training and career development programs to develop skills in key areas such as data management, biostatistics, manuscript preparation, etc. The post-doctoral fellow will receive direct mentorship from Dr. Vanderver and other senior scientists within the laboratory, tailed to training program within the lab will be individually tailored to prepare for their desired next career steps. This position also involves external collaboration with other key leaders in the field of leukodystrophy.
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Dr. Vanderver is a co-founder of the Global Leukodystrophy Initiative Clinical Trials Network (GLIA-CTN), a Rare Diseases Clinical Research Network (RDCRN) consortium funded under grant number U54NS115052 in collaboration between the National Center for Advancing Translational Sciences (NCATS) and the National Institute of Neurological Disorders and Stroke (NINDS). The post-doctoral fellow will have opportunities to participate in grant-funded research collaborations, and attend/present at various scientific meetings and seminars.


Responsibilities:

1. Conduct independent scholarly research and develop new methods and protocols
2. Participate in project planning, recording and evaluation of data
3. Acquire technical, lab management and grant writing skills
4. Participate in seminars, lectures, poster sessions and presentation at national meetings
5. Supervise junior lab members
6. Assist with other research projects


Qualifications/Preferred Skillsets:

-A terminal degree PhD, MD, DVM, etc.
-According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing
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All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.
Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.
Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.
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VEVRAA Federal Contractor/Seeking priority referrals for protected veterans. Please contact our hiring official with any referrals or questions.
CHOP Careers Contact
Talent Acquisition
2716 South Street, 6th Floor
Philadelphia, PA 19146


Link to Application (if using external Application Portal): https://careers.chop.edu/job/Philadelphia-Res-Post-Doc-Fellow-Basic-Science-Post-Doctoral-Fellow-Leukodystrophy-Center-PA-19104/752987600/?locale=en_US
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