UUtah Salt Lake City, UT, USA
A postdoctoral position to study innate immune signaling pathways and inflammation is available immediately in the Microbiology & Immunology Division, University of Utah, Department of Pathology.
The research project is aimed at deciphering the cellular and molecular regulation of innate immunity in the context of inflammatory and autoimmune disease. In particular, we study the function of Toll-like receptors (TLRs), which are essential for pathogen recognition, but can also promote inflammatory and autoimmune diseases. In previous work we identified a key negative regulator of Toll-like receptor (TLR) signaling pathways, which is essential for protection from inflammatory diseases (Nature 2006 PMID: 16306937; PNAS 2009, PMID: 22011580; PNAS 2016, PMID: 27671649, JCI 2019, PMID: 31033479). The goal of this project is to reveal the signaling mechanisms and genes controlling TLR biology and their impact on in vivo immunity and inflammation. The long-term goal is to identify novel targets for therapeutic intervention in inflammatory human diseases.
For more information related to the lab, the breadth of resources at the University of Utah and the stunning environment of Salt Lake City/ Utah please see: https://medicine.utah.edu/pathology/research/labs/hans-haecker/
To apply, please send a cover letter as well as CV including publication history and three professional references to Dr. Hans Haecker, Professor at the Microbiology & Immunology Division of the Pathology Department, University of Utah, using the following link: https://utah.peopleadmin.com/postings/106232Responsibilities:
The project provides an ideal opportunity for fellows who are interested in (i) innate immunity and inflammation regulation, (ii) molecular mechanisms of signal transduction, applying cutting edge protein identification/ interaction analyses, such as quantitative MS and (ii) regulation of innate immune effector functions, in vitro and in vivo.
Applicants should hold a PhD and/or MD degree in Biochemistry, Biology or Immunology. The ideal candidate should have expertise in molecular biology and protein analysis and, preferably, experience with animal (mouse) in vivo experimentation.