Post-doctoral Fellow, University of Washington

  • Postdoc
  • Understanding how mutations in specific actin-regulatory or metabolism regulatory proteins result in primary immunodeficiency diseases

Seattle, WA


Description:

The Iritani laboratory at the University of Washington has immediate availability for a Postdoctoral scholar in Cellular and Molecular Immunology. The start date would be Fall/Winter 2022 or sooner. The overall goals of the laboratory are to define the roles of specific signaling proteins in the development, functions, and transformation of immune cells. Potential projects will focus on utilizing murine models to define how loss-of-function mutations in specific genes result in Primary Immunodeficiency Diseases (PIDs) and autoimmunity. Project 1 involves investigating the mechanisms of how LOF mutations in Fnip1 alter immunometabolism and lymphocyte development (see Park et al., Immunity (PMID 22608497); Park et al., PNAS (PMID 24785297); Reyes et al., PNAS (PMID 24785297); Iritani et al., Blood (PMID 33507298)). Project 2 focuses on investigating how LOF mutations in a hematopoietic cell-specific actin regulatory protein alter the development and functions of macrophages, T cells, or B cells (see Park et al., Journal of Experimental Medicine (PMID 19015308); Suwankitwat et al., Journal of Experimental Medicine (PMID 33600594); Peters et al Nat Genetics (PMID 28892060). Successful candidates will utilize a variety of innovative technology including metabolomics, transcriptomics, epigenomics, proteomics, live cell imaging, and humanized mice.
The University of Washington is one of the world’s most preeminent public universities, located in beautiful Seattle. In 2020, the UW was ranked 10th by the US News and World Report’s Best Global Universities.
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Postdoctoral scholars are represented by UAW 4121 and are subject to the collective bargaining agreement, unless agreed exclusion criteria apply. For more information, please visit the University of Washington Labor Relations website.



Qualifications/Preferred Skillsets:

Candidates should have a Ph.D., or equivalent degree in Immunology or Molecular and Cellular biology. Additional qualifications include specific expertise in working with transgenic and knockout mice; utilizing flow cytometry to dissect immune cell development and functions; utilizing immunoblotting to assess cell signaling; and basic molecular biology techniques. Expertise in metabolomics and/or live cell imaging are a plus. Qualifications also include strong interpersonal skills, excellent organizational skills, and interests in mentoring undergraduate and graduate students, and collaborative attitude. A solid publication record as well as eligibility and desire to apply for future fellowships are helpful.



Featured Publications:

Project 1 involves investigating the mechanisms of how LOF mutations in Fnip1 alter immunometabolism and lymphocyte development (Park et al., Immunity (PMID 22608497); Park et al., PNAS (PMID 24785297); Reyes et al., PNAS (PMID 24785297); Iritani et al., Blood (PMID 33507298)). Project 2 focuses on investigating how LOF mutations in a hematopoietic cell-specific actin regulatory protein alter the development and functions of macrophages, T cells, or B cells (see Park et al., Journal of Experimental Medicine (PMID 19015308); Suwankitwat et al., Journal of Experimental Medicine (PMID 33600594); Peters et al Nat Genetics (PMID 28892060).


Something about the PI: The PI is an avid outdoorsperson with specific passions towards traveling and fishing
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