Postdoctoral Fellow in Immunogenomics, Univ. of Washington

  • Postdoc
  • Determine how autoimmune-associated variants at cis-regulatory elements alter 2D and 3D chromatin structure.
  • Applications have closed
Lab Website: www.hawkinslab.org

hawkins_lab Seattle, WA, USA


Description:

We currently have a Postdoctoral Fellow position available for a chimeric (wet/dry) scientist to specialize in cis-regualtory genomics and epigenomics. This position is for an NIH-funded project through the 4D Nucleome consortium focused on investigating 2D gene regulation and 3D genome architecture, and the relationship to autoimmune diseases/disorders. We are studying disease-associated variants within cis-regulatory elements (CREs; such as enhancers) using massively parallel reporter assays and chromatin QTL mapping (ATAC-seq) from donor samples, and identifying CRE target genes using 3D genome architecture (Hi-C based methods). CRISPR editing in primary T cells is used for validation studies. The successful applicant will have the opportunity to lead on this project including wet lab data generation, help with data analysis of these genome-wide datasets and collaborate with our colleagues using functional system immunology as validation.


Responsibilities:

Perform ATAC-seq, capture Hi-C, CRISPR editing in primary T cells. Some bioinformatics analysis.


Qualifications/Preferred Skillsets:

Candidates should have experience in epigenomics, gene regulation and/or immunology. Background in immunology, genomics, epigenomics, CRISPR editing, and/or gene regulation preferred. Demonstrable skills in bioinformatic and data visualization are a plus. Good written and verbal communication skills are required. Must be highly motivated, but can’t take yourself too seriously, and get along well with others.


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