Postdoc, Washington University in St. Louis

  • Postdoc
  • Causes & Consequences of DNA Damage in Cancers
  • Applications have closed
Lab Website: www.vermalab.org

priyanka13verma St Louis, MO, USA


Description:

The Verma Lab in the Division of Oncology at the School of Medicine, Washington University, St. Louis, MO is seeking a highly motivated postdoctoral fellow interested in studying the cause and consequences of DNA damage in cancers. Several projects are available based on the relevant expertise and interest of the candidate. These include:

• Elucidating the impact of defective checkpoint signaling on DNA replication
• Investigation of biochemical alterations in DNA in BRCA-mutant cancers
• Deciphering the mechanistic basis of mutational signatures in cancer genomes


Responsibilities:

The lab is committed to the professional development of the candidate. Our lab is a core member of the Center of Genome Integrity (CGI) at the Washington University, which integrates several leading experts in the field of DNA repair. Additionally, the diverse research expertise and strong clinical environment at the medical campus provides a unique opportunity to steer projects in several directions. Candidate will develop strong skills in several molecular and cell biology tools including advanced CRISPR genetic screening and editing, high resolution mass spectrometry and various high-end imaging and flow cytometry platforms. Candidate will also further their skills in manuscript and grant writing, oral presentations as well as mentoring undergraduates and graduate students. The vibrant and collegial scientific atmosphere at Washington University will also be a catalyst for professional growth.


Qualifications/Preferred Skillsets:

•Candidate should have a PhD or MD/PhD
•Strong ability to grasp concepts of molecular biology and mechanistic cell biology
•Enthusiasm to do innovative science
• Good organization and communication skills are a must
•Experience in functional genomics, computational biology or mouse genetics is preferred but not essential



Featured Publications:

1. Verma P., Zhou Y., Cao Z., Deraska P., Arai E., Deb M., Li W., Li Y., Patankar S., Faryabi RB., Shi J.,
Greenberg RA. ALC1 and PARP activities coordinate chromatin accessibility and viability in homologous
recombination deficient cells. Nat Cell Biol., 23(2),160-171,2021.
2. Verma P., Dilley RL, Zhang T, Gyparaki MT, Li Y, Greenberg RA. RAD52 and SLX4 act nonepistatically
to ensure telomere stability during alternative telomere lengthening. Genes Dev. 33, 221-235, 2019.
3. Verma P., Greenberg RA. Communication between chromatin and homologous recombination. Curr.
Opin. Genet. Dev., 71, 1-9,2021.
4. Dilley RL., Verma P., Cho NM., Winters HD., Wondisford A., Greenberg RA. Break-induced telomere
synthesis underlies homology-directed telomere maintenance. Nature. 539, 54-58, 2016.


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